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Preface
It turns out that Relypsa, Inc. (NASDAQ:RLYP) largest institutional shareholders are buying more stock as news coming out of the company is turning more bullish.

While Relypsa, Inc. is often caught up in takeover rumors surrounding firms from AstraZeneca (NYSE:AZN), to Merck (NYSE:MRK), Biogen (NASDAQ:BIIB), Pfizer, Inc. (NYSE:PFE) and its partner Sanofi (NYSE:SNY), recently the stock is up on real news.

First, on May 23rd Relypsa, Inc. rose on new data that the company presented surrounding its drug Veltassa which showed the following:

“
Patients with heart failure and chronic kidney disease often have restricted fluid and sodium intake, as these may cause congestive symptoms.

We presented new data suggesting Veltassa may bind and remove sodium as well as potassium in the gastrointestinal tract, which may be relevant for these patients.

”

Source: GlobeNewswire

The new data revealed that:
* Daily administration of Veltassa resulted in a dose-related decrease in mean urine sodium compared with placebo (p=0.009 across Veltassa doses).

* No serious adverse events were reported, and no study participants discontinued treatment because of an adverse event.

Second, and most urgently, Relypsa’ s only competitor in the Hyperkalemia space, AstraZeneca's acquired ZS-9, was given a complete response letter (CRL) from the FDA, which in English means, a full rejection of the filing for approval.

The CRL surrounded manufacturing issues with ZS-9, not clinical data. However, that CRL will push the ZS-9 product launch out at least another year and the drug still has issues surrounding its tendency to create sodium in the blood, which is a critical side effect for patients that have Hyperkalemia and may mean the drug will be prevented from treating the largest portion of the market -- chronic cases.

But now we got more news.

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INSTITUTIONS ARE BUYING
The good news surrounding Relypsa, Inc. has pushed the stock up 40% in recent weeks and the buying appears to be coming from the company's largest institutional shareholders. Here is a list of the eleven largest holders of Relypsa, Inc. (NASDAQ:RLYP) stock and the change since the prior SEC filings:

Data From: whalewisdom.com
Compilation By: Capital Market Labs

While the largest shareholder, Orbimed, saw no change, the next seven largest holders increased their holdings. In total, of the eleven largest holders, eight bought more stock, two sold stock and one was unchanged. The result is an increase of nearly 3.2 million shares on a total stock float of just 31.8 million shares. Institutional shareholders own more than 85% of the Relypsa, Inc. stock as of this writing, and 11% is held by insiders.

The author is long Relypsa call options in his personal account.

SEEING THE FUTURE
There's so much going on with Relypsa we can't cover it all in one report but it is one of the few precious "Top Picks" named by CML Pro.

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These are just two of the themes we have identified and this is just one of the fantastic reports CML Pro members get along with all the visual tools, the precious few thematic top picks for 2016, research dossiers and alerts. For a limited time we are offering CML Pro at a 90% discount for $10/mo. with a lifetime guaranteed rate. Join Us: Get the most advanced premium research delivered to your inbox along with access to visual tools and data that until now has only been made available to the top 1%.

Thanks for reading, friends.


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